Uric Acid Lowering to Prevent Kidney Function Loss in Diabetes: PERL Allopurinoal Study
Author(s)
Dr Mujtaba Ali Hasnain , Dr Zubair Anwar , Dr Abdul Rehman ,
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Abstract
Significant morbidity and mortality is caused by diabetic kidney disease in people around the globe with type 1 diabetes. Previously, intensive focus was on blood pressure and glucose control which proved to be less effective and as a failure in preventing the progression of the disease and curbing it. Multiple studies have shown the significance of lowering uric acid levels in treating diabetic kidney disease and preventing its progression. This review paper includes a trial conducted by the Preventing Early Renal Function Loss (PERL0 Consortium using allopurinol, in lowering the uric acid level and stating that such novel interventions much be tested for positive outcomes. Although the trial targeted diabetes type 1 patients, but the use or allopurinol as a renoprotective agent was found effective in a large number of population. It is inexpensive, safe to use and is cost effective for patients who are at lower risk and going through initial disease stages
Keywords
Uric Acid, Kidney Function loss
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