Understand the Burden of MDR TB in DHQ/Teaching Hospital Gujranwala
Author(s)
Dr. Farhan Tahir , Dr. Hina Arshad , Dr. Marriam Liaquat ,
Download Full PDF Pages: 33-38 | Views: 1174 | Downloads: 326 | DOI: 10.5281/zenodo.3455932
Abstract
Resistance to anti-tuberculosis (TB) medicines is a major public health threat in most countries of the World. As small no. of representative and quality-assured information on the magnitude of this problem existed in Pakistan, a survey was conducted in the DHQ/Teaching Hospital Gujranwala.Between January 2017 and January 2018, 212 consecutively diagnosed new culture-positive TB patients residing in District Gujranwala were enrolled in the survey.Mycobacterium tuberculosis isolates were obtained from each patient and tested for susceptibility to Rifampin Resistant. Multidrug-resistant (MDR)-TB was found in 19.2% of new patients. Overall, nearly one in 8 patients enrolled had MDR-TB. Patients with less than 25 yrs of age have shown a higher odds ratio of multi-drug resistant TB than those aged >55 yrs.The findings of this survey in Gujranwala District are alarming and represent the high proportions of MDR-TB . This study greatly contributes to the understanding of the burden of drug-resistant TB in urban areas of Gujranwala
Keywords
Epidemiology, Gujranwala Medical College Gujranwala ,multidrug-resistant tuberculosis, surveillance
References
i. World Health Organization Global tuberculosis control: surveillance, planning, financing,
ii. WHO report 2008 Accessed 28 March 2008 Available at: http://www.who.int/tb/publications/global_report/2008/pdf/fullreport.pdf
iii. Joint United Nations Programme on HIV/AIDS (UNAIDS), World Health Organization
iv. AIDS epidemic update: November 2007 Accessed 28 March 2008 Available at: http://www.unaids.org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArchive/2007/default.asp
v. World Health Organization XDR TB—extensively drug-resistant TB, November 2006: outcomes of the WHO Global Task Force on XDR TB, October 9–10 Accessed 28 March 2008 Available at: http://www.who.int/tb/xdr/xdr_nov06_en.pdf
vi. World Health Organization Tuberculosis fact sheet Accessed 28 March 2008 Available at: http://www.who.int/mediacentre/factsheets/fs104/en/index.hml
vii. World Health Organization. Guidelines for the programmatic management of drug-resistant tuberculosis: emergency update. WHO/HTM/TB/2008.402. Geneva, World Health Organization. Available from: http://whqlibdoc.who.int/publications/2008/9789241547581_eng.pdf
viii. Skrahina, Alena, et al. "Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk." European Respiratory Journal 39.6 (2012): 1425-1431.
ix. world Health Organization. Treatment of tuberculosis: guidelines for national programmes. 4th Edn. WHO/HTM/TB/2009.420. Geneva, World Health Organization, 2009. Available from: http://whqlibdoc.who.int/publications/2010/9789241547833_eng.pdf
x. World Health Organization. Guidelines for surveillance of drug resistance in tuberculosis. 4th Edn. WHO/HTM/TB/2009.422. Geneva, World Health Organization. Available from: http://
xi. whqlibdoc.who.int/publications/2009/9789241598675_eng.pdf
xii. World Health Organization. Multidrug and extensively drugresistant TB (M/XDR-TB): 2010 Global Report on Surveillance and Response. WHO/HTM/TB/2010.3. Geneva, World Health Organization. Available from: http://whqlibdoc.who.int/publications/2010/9789241599191_eng.pdf
xiii. Wright A, Zignol M, Van Deun A, et al. Epidemiology of antituberculosis drug resistance 2002–07: an updated analysis of the Global Project on Anti-Tuberculosis Drug Resistance Surveillance.
xiv. Lancet 2009; 373: 1861–1873.
xv. Skrahina A, Astrauko A, Hurevich H, et al. Multidrug resistance and its influence on TB treatment results in the Republic of Belarus. Lechebnoe Delo (Minsk). Issue 5 (15), 2010; pp. 17–21.
xvi. Skrahina A, Astrauko A, Hurevich H. Tuberculosis and drug resistant tuberculosis monitoring system. Proceedings of the 4th International Research and Practical Conference on Actual Problems of Penitentiary Medicine, Tuberculosis and Other Socially Important Diseases in Prisons (Minsk, September 2009); pp. 88–93.
xvii. Skrahina A, Astrauko A, Hurevich H. Drug resistance trends among tuberculosis patients registered in dispensaries. Proceedings of the 4th International Research and Practical Conference on Actual Problems of Penitentiary Medicine, Tuberculosis and Other Socially Important Diseases in Prisons (Minsk,September 2009); pp. 75–81.
xviii. Skrahina A, Astrauko A, Hurevich H. The problem of multidrug resistance among TB and TB/HIV patients in the Republic of Belarus. Proceedings of the 7th Congress of Physiologists of Belarus TB diagnostic and treatment in light of DOTS strategy (Minsk, May 2008); pp. 69–90.
Cite this Article: